Affective disorders arise in stressful situations from aberrant sensory information integration that affects energetic nutrient (i.e., glucose) utilization to the cognitive centers of the brain. Because energy flow is mediated by molecular signals and receptors that evolved before the first complex brains, the phylogenetically oldest signaling systems are essential in the etiology of affective disorders. The corticotropin‐releasing factor (CRF) peptide subfamily is a phylogenetically old metazoan peptide family and is pivotal for regulating organismal energy response associated with stress. Highly conserved, (...) both the CRF peptide family and its receptors possess a structural relationship to the teneurins, and their receptors, latrophilins, respectively. The CRF homologous region of teneurin is defined as the “teneurin C‐terminal associated peptide” (TCAP) and antagonizes CRF action, regulates mitochondrial energy production, and is anxiolytic in vivo. Here, it is postulated that TCAP represents an ancient peptide that mediates intercellular information transfer of stressful and noxious events by regulating energy utilization among neurons. (shrink)

Graphical AbstractIn neurons, teneurins and latrophilins form a juxtacrine unit that originated in the earliest metazoans. The ‘teneurin C-terminal associated peptide’ (TCAP) regulates mitochondrial function to coordinate energy usage in surrounding cells. TCAP inhibits stress-related actions of corticotropin-releasing factor (CRF) in the central nervous system and may underlie the etiology of some affective disorders. More details can be found in article number 2000039 by David A. Lovejoy and David W. Hogg. Cover image by Mia Husic.

A correction to this paper has been published: https://doi.org/10.1007/s10551-021-04780-w.

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In this study, Daniel W. Graham addresses two major problems in interpreting Aristotle. First, should we reconcile the apparent inconsistencies of the corpus by assuming an underlying unity of doctrine, or by positing a sequence of developing ideas? Secondly,what is the relation between the so-called logical works on the one hand and the physical-metaphysical treatises on the other? Although the problems appear to be unrelated, Graham finds that the key to the first lies in the second, and in doing so (...) provides the first major alternative to theunitarian approach since Jaeger's pioneering developmental study of 1923. (shrink)

AT PHAEDO 96A-C Plato portrays Socrates as describing his past study of "the kind of wisdom known as περὶ φυσέως ἱστορία." At 96c-97b, Socrates says that this study led him to realize that he had an inadequate understanding of certain basic concepts which it involved. In consequence, he says at 97b, he abandoned this method and turned to a method of his own. But at this point in the dialogue, instead of proceeding immediately to describe his method, Plato has him (...) interjecting a complaint concerning Anaxagoras and his view that everything should be explained in terms of Mind. His complaint is that Mind would order things in the best possible way and that, therefore, an account of things in terms of Mind would amount to showing that they are ordered in the best possible way. But Anaxagoras did not show this and, instead, offered other kinds of explanations of the various phenomena. Socrates is not just criticizing Anaxagoras here for not doing what he set out to do; he makes it clear, for example at 99b-c, that he believes that the best kind of explanation of the phenomena would be to show that they are ordered in the best possible way. But he was unable to discover an explanation of this kind, either for himself or from others, and so turned to a method which he calls "second best". The actual description of this method is contained in two passages, 99e5-100a7 and 101d5-e1. Between these passages, Socrates invokes the doctrine of Forms and, in particular, the formula. (shrink)

Spanning pivotal years in the historic democratization of South Africa, this analysis provides a trenchant reflection of higher education in transition. Penned by one of South Africa’s foremost philosophers of education, the critique grapples with very real concerns in higher education policymaking and practice, including stakeholder politics, institutional cultures, and curriculum transformation and interrogation of the function of higher education institutions in modern societies. Exposing the tensions between egalitarian principles and the nature of higher knowledge, the essays raise questions to (...) which there are no simple answers. With characteristic rigor, the analysis looks into the assumptions underlying much of the thinking about these questions and concludes that a failure to sharpen thinking around higher education is a failure to recognize the epistemic value of academic practice in a developing democracy. (shrink)

L'A. soutient, contre Germain Grisez, Joseph Boyle, John Finnis et William May, que le contrôle naturel des naissances pratiqué avec une intention mauvaise n'est pas contraception. Il montre que les auteurs identifient de façon incorrecte la fin prochaine de la contraception comme choix qu'il n'y ait pas d'enfant, alors que la fin prochaine véritable est d'empêcher un enfant de venir au monde . Ainsi donc, puisque en NFP un couple ne cherche pas à empêcher la venue au monde d'un enfant, (...) NFP n'implique pas d'action contraceptive. L'A. soutient aussi qu'identifier la fin prochaine comme choix qu'il n'y ait pas d'enfant ne spécifie pas de façon adéquate une classe homogène d'actes objectifs, bien que cela spécifie une classe homogène d'actes moraux. (shrink)

In Rethinking the Philosophy of Religion Today, this paper would like to advance the atheist solution to the problem of evil that has occasionally in the past been suggested by philosophers, but has largely been neglected in the Philosophy of Religion. In discussing this solution, the paper focuses on the reasons upon which philosophers regard the giving up of one or more of the attributes of God in theism to be an adequate solution to the problem of evil. Concerning the (...) more negative of these reasons, it shows that the latter revolves around the argument of the logical inconsistency of the theistic theory. Concerning the more positiveof these reasons, the focus is on the efforts of philosophers that have been following the suggestions of David Hume and that have started to experiment with solutions wherein at least one of the attributes of God is given up. The paper closes by showing that there exist an even more fundamental reason upon which it can be claimed that the problem of evil can be solved along this way without serious implications for a belief in God. (shrink)

William Cunningham was a prominent British economist and economic historian. In this book, which was first published in 1917, Cunningham provides a concise guide to various aspects of political philosophy, with a particular focus on British political institutions. Appendices are included and textual notes are incorporated throughout. This book will be of value to anyone with an interest in political philosophy and the nature of governance.